Published Studies

Stanate, known generically as Stannsoporfin, and chemically as tin-mesoporphyrin (SnMP) has been shown successful in numerous clinical trials. The results of these trials have been published in the following journals and can be accessed through the provided links:

In the following article based on the results of a clinical trial in preterm newborns, SnMP was shown to successfully inhibit the production of bilirubin.
Valaes T, Petmezaki S, Henschke C, Drummond GS and Kappas A. Control of Jaundice in Preterm Newborns by an Inhibitor of Bilirubin Production: Studies with Tin-Mesoporphyrin. Pediatrics 93(1):1-11 1994.

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Dr Kappas reports on a method for effectively controlling the production of bilirubin in newborns. The method involved using SnMP, an inhibitor that is targeted directly at the enzyme that controls heme degradation to bilirubin. Using SnMP permits physicians to rapidly, and predictably, control
hyperbilirubinemia at any point in the progression of jaundice.
Kappas A. A Method for Interdicting the Development of Severe Jaundice in Newborns by Inhibiting the Production of Bilirubin. Pediatrics 113 (1) 119-123 January 2004.

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The following article reports on, G-6-PD-deficient neonates who, in comparison with normal neonates, experience a twofold increase in the prevalence of significant hyperbilirubinemia requiring phototherapy. A single dose of SnMP administered in the 1st day of life to the G-6-PD-defident newborns shifted the peak PBC distribution to the left (lower values) even in relation to normal neonates and entirely eliminated the need for phototherapy.
Kappas, A, Drummond, G and Valaes T. A Single Dose of Sn-Mesoporhyrin Prevents Development of Severe Hyperbilirubinemia in G-6-PD Deficient Newborns. Pediatrics Vol. 108 (1) 25-30 July 2001.

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In G6PD-deficient neonates, a single dose of SnMP administered preventively or therapeutically entirely supplanted the need for PT to control hyperbilirubinemia.
Valaes T, Drummond GS, and Kappas A. Control of Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-deficient Newborns Using an Inhibitor of Bilirubin Production, Sn Mesoporphyrin. Pediatrics 101(5):1-7 1998.

Dr Martinez reports that a single dose of SnMP proved effective in controlling severe hyperbilirubinemia in full-term breastfed newborns with high bilirubin levels between 48 and 96 hours.
Martinez J, Garcia H, Otheguy L, et al. Control of Severe Hyperbilirubinemia in Full-term Newborns with the Inhibitor of Bilirubin Production, Sn Mesoporphyrin. Pediatrics 103(1):1-5 1999.

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A single dose of SnMP entirely supplanted the need for PT In jaundiced term and new-term newborns and significantly reduced the medical resources used to monitor hyperbilirubinemia.
Kappas A, Drummond GS, Henschke C, and Valaes T. Direct Comparison of Sn-Mesoporphyrin, an Inhibitor of Bilirubin Production, and Phototherapy in Controlling Hyperbilirubinemia in Term and Near-Term Newborns. Pediatrics 95(4):468-474 1995.

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The study demonstrated that a single dose of SnMP, administered to healthy full -term breast-fed newborns at a time when hypehilirubinemia is becoming severe could eliminate the need for PT and reduce both the number of bilirubin measurements and the length of time the infants are under clinical care for the problem of hyperbilirubinemia.
Martinez J, Garcia H, and Otheguy L, et al. Treatment of Hyperbilirubinemia Pharmacologic Approach SnMP (Tin-Mesoporphyrin). Journal of Perinatology Vol. 21 (supplement 1), 101s-103s December 2001.

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Click here for a selection of articles regarding hyperbilirubinemia and its treatment.